The main finding in brains of people with PD is loss of dopaminergic neurons in the … Parkinsonism and Related Disorders. Initial pharmacologic treatment of Parkinson disease. When dopamine levels decrease, it causes abnormal brain activity, leading to symptoms of Parkinson's disease.The cause of Parkinson's disease is unknown, but several factors appear to play a role, including: 1. These include pesticides such as insecticides, herbicides, and fungicides. It crosses the blood-brain barrier , potentially enabling it to remove the iron that accumulates to toxic amounts in the brains of Parkinson’s patients. The McGraw-Hill Companies; 2018. https://accessmedicine.mhmedical.com. Prog Brain Res. https://www.uptodate.com/contents/search. Parkinson’s disease (PD) is a disorder that occurs throughout your body’s nervous system, and affects your muscle movement and coordination. Learn about symptoms, how it is diagnosed and what treatment options are available. Accessed May 29, 2018. 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